By Crash News Writer 
Greenwood Village, CO (September 26, 2025) – A serious multi-vehicle accident Thursday evening shut down all southbound lanes of Interstate 25 at Orchard Road in Greenwood Village and left six people hospitalized.
According to the Colorado State Patrol, the crash was first reported by South Metro Fire Rescue around 6:52 p.m. on September 25. Emergency responders arrived on scene near Arapahoe Road and found multiple vehicles involved in a severe collision, including at least one that leaked fuel, prompting a hazmat response.
Six patients were transported to nearby hospitals for treatment. Their current conditions have not been disclosed.
Traffic in the southbound lanes was backed up nearly three miles, stretching to the intersection of I-25 and I-225 near the Denver Tech Center.
Meanwhile, a separate commercial vehicle fire was reported on northbound I-25 near the same location, further complicating traffic in the area.
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PLEASE TAKE NOTICE
This article is based on official reports and may be updated as more details are confirmed by investigators. If you have questions about your next steps, see our frequently asked questions in Colorado.
The exact cause of the crash has not been released. Officials continue to assess whether road conditions, vehicle defects, or driver behavior contributed.
Both the multi-vehicle accident and the commercial vehicle fire led to prolonged delays on Interstate 25 Thursday evening.
For additional help, including local contacts and medical support, visit our accident resources in Colorado.
This content is for informational purposes only and not intended as legal or medical advice. Facts may change as investigations proceed. Please read our full disclaimer.
If you or someone you love was involved in a crash in Colorado, call an attorney as soon as possible to discuss your legal options.